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In a study of induced osteoarthritis in rats, the authors demonstrated that spermidine supplementation reduced pyroptosis and proinflammatory cytokine production and limited pathological processes in the joints (Reference Guo, Feng and Yang88)

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Apesar da curta meia-vida plasmtica, os efeitos biolgicos downstream no tecido persistem substancialmente mais tempo, consistente com uma cascata de sinalizao e no com uma simples relao dose-resposta direta

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