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Mark Hyman, MD, is the founder of the Cleveland Clinic Center for Functional Medicine

Your body has adapted to GLP-1 activation from semaglutide, but it has never experienced GIP activation

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The article described how the administration of an anti-mouse GIPR antibody (muGIPR-Ab) prevented weight gain in diet-induced obesity (DIO) mice, improved various metabolic parameters, and was associated with a reduction in food intake and the resting respiratory exchange ratio

Compounded tirzepatide follows the same titration logic, though concentrations and preparation may vary