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Further studies are needed to clarify the mechanisms by which L-carnitine protects ovarian functions and follicular development

During oxygenated or oxygen-deprived states, hypoxia-inducible factor 1 (HIF-1) promotes Th17 differentiation by directly transcriptionally activating RORt and facilitating the formation of a tertiary complex comprising RORt, p300, and HIF-1 at the IL-17 promoter region [41]

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Thus, it is suggested that NaBPC157 is able to prevent vaginal atrophy in rats caused by castration