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Although the association between IBD and insulin resistance and MASLD is controversial, visceral fat is gaining prominence as a predictive prognostic factor of postoperative recurrence in CD patients

The 10mg dose appears to be a particular inflection point, with heartburn rates roughly doubling compared to the 5mg dose

The caveat: retatrutide's figure comes from Phase 2 (smaller n, larger selection effects), while tirzepatide's data is Phase 3-mature

Slower injections are less painful

Unknown factors include potential hormonal effects, cellular signaling imbalance, and unintended tissue growth responses after prolonged exposure

Vomiting can occur, particularly with large or rich meals