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To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]

PKCII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

Absorbance was measured at 450 nm at an EnSpire multimode plate reader (PerkinElmer, Singapore)

Researchers working with human subjects can track outcomes using several practical approaches