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Bacteriostatic water also can't be used for IV administration without an isotonic admixture, because plain bacteriostatic water without a solute is hypotonic and can cause hemolysis on IV push

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And do they degrade if they are not? This concern is often based on commonly held assumptions that are not always supported by relevant data

Any condition affecting the gastrointestinal tract, such as autoimmune gastritis (which can lead to pernicious anaemia), celiac disease, Crohns disease, or surgical procedures like gastric bypass surgery, gastrectomy or terminal ileal resection, can impair the absorption of B12, and increases the chance of developing vitamin B12 deficiency

Compared to the defensins they have additional advantages

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