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Similarly, various senescent cell types have been identified in postmortem AD brain tissue including astrocytes (38), neurons (35, 39), microglia (40), oligodendrocyte precursor cells (37), and endothelial cells (41)

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Activation of S1PR2 by specific BAs, particularly conjugated BAs such as taurocholic acid (TCA), stimulates the RhoA/ROCK1 signaling axis in macrophages, facilitating M1 polarization and NLRP3 inflammasome activation

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