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ChaC-like enzymes act specifically on GSH, GGACT enzymes act on -glutamylamine amino acids, and GGCTs have a broader activity towards -glutamyl amino acids in general

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Integration provides a principled way to reduce dependence on any single noisy layer, recover cross-layer programs that better reflect system function, and define biologically interpretable endotypes that can generate hypotheses for triage decisions or targeted interventions [70]

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