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However, eribulin directly acts on angiogenesis-associated pathways, including VEGF ( Vegfa , Vegfr1 , Vegfr2 , and Vegfr3 ), Notch ( Dll4 , Jag1 , and Notch4 ), Eph ( Efnb2 , Epha2 , and EphB1 ), and WNT ( Wnt5a , Wnt11 , and BPM4 ), thus resulting in vascular remodeling

Its unusually broad activity profile

doi: 10.1007/s10571-023-01417-6 19 ButterfieldD

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At HormoneSynergy Clinic (Portland & Lake Oswego, Oregon), Dr