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Both approaches work
For example, in a mouse model of mucopolysaccharidosis (MPS VII), transgene delivery of b-glucuronidase in neonatal mice using an AAV2 vector resulted in the mice developing hepatocellular carcinoma (HCC)with evidence of AAV integration within the tumors [149, 150]
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Ocular pharmacokinetics of bimatoprost formulated in DuraSite compared to bimatoprost 0.03% ophthalmic solution in pigmented rabbit eyes
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10.4161/cc.7.7.5625 147 PozziE.TerribileG.CherchiL.Di GirolamoS.SanciniG.AlbertiP
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