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However, suppression of mTORC1 activity either physiologically by starvation, stress, and certain immunological signals or pharmacologically by rapamycin triggers its dissociation from the ULK1 complex, thus enabling ULK1 to induce autophagy (Ravikumar et al., 2009

Luteolin also reduces the amount of TBK1-dependent gene expression by inhibiting TBK1-kinase activity, and IRF3 dimerization and phosphorylation

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Semaglutide is a GLP-1 agonist only, Tirzepatide is a dual GLP-1/GIP agonist

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