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Based on this finding, two incretin-based medications were developed: (1) DPP-4 inhibitors that increase the concentration of GLP-1 by inhibiting it [22], and (2) GLP-1RAs, which act directly on the GLP-1 receptor [23]

In a Phase 2 trial, weight loss with the CagriSema combination reached approximately 15.6%, compared with cagrilintide monotherapy at ~8.1% and semaglutide monotherapy at ~5.1%

In experimental models, researchers explore processes such as angiogenesis, wound healing, and signaling associated with chronic inflammation

The difference likely relates to specific protocols, skin types, and individual responses

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PubMed Simeon A et al