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Trends in Endocrinology and Metabolism (2017) 7

10.3389/fcell.2018.00049 88

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Abstract Acetaminophen (APAP)-induced acute liver injury (AILI) is primarily driven by CYP3A4mediated overproduction of the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI), CYP3A4 activity serves as the rate-limiting determinant of NAPQI accumulation levels

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