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However, the evidence was rated as low quality because the studies showed a high risk of bias

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Accordingly, although our results suggest tirzepatide confers cardiovascular benefits at least comparable to the GLP-1RA class, confirmation from adequately powered randomized head-to-head cardiovascular outcome trials will be important to define the magnitude of benefit

Experts are firmly in the food-first camp real food provides fiber, protein and other nutrients that no supplement can replicate but GLP-1 supplements are often worth considering