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J Biol Chem 278:2802628037 Chondrogianni N, Tzavelas C, Pemberton AJ, Nezis IP, Rivett AJ, Gonos ES (2005) Overexpression of proteasome 5 subunit increases amount of assembled proteasome and confers ameliorated response to oxidative stress and higher survival rates

Although traditionally considered an inflammatory disorder of white matter, more recently it has become apparent that gray matter damage is also prominent and widespread, though the immune responses are less pronounced in this region, and therefore the radiological and pathological signatures more subtle

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This controlled degradation allows space for new, healthy matrix deposition