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Discovery of a potent, selective, and orally bioavailable c-met inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

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Its ability to influence gene expressionreportedly altering the activity of thousands of genesprovides a powerful model for investigating how cellular function can be modulated towards a regenerative state

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