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Pregnancy and lactation: Insufficient safety data exists for MOTS-c use during pregnancy or breastfeeding

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doi: 10.1016/S0140-6736(15)00803-X 36 BendottiGMontefuscoLLunatiMEUsuelliVPastoreILazzaroniEet al

In the SURMOUNT-5 trial (NEJM, 2025), tirzepatide reduced body weight by 20.2% versus 13.7% for semaglutide over 72 weeks

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