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The ISR maintains or restores the proteostasis of multiple organelles, such as the ER, mitochondria, and Golgi apparatus, thereby controlling cellular behavior, metabolism, and survival

Preprint at Res

Nat Rev Endocrinol 8(3):160171

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It has been noted that younger children may be less susceptible to APAP-induced hepatotoxicity because of increased glutathione stores or metabolism differences as a result of genetic variability (Pineiro-Carrerro and Pineiro, 2004)

Its also one of the most powerful antioxidants