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Gastrointestinal Side Effects and Their Timeline Nausea remains the dominant side effect reported in Ozempic users, affecting roughly 25-35% of patients in clinical trials

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For example, in the SURPASS-2 study, TZP at the dose of 5, 10, and 15 mg reduced HbA1c by -2.18% vs -1.86% with semaglutide and weight by -9.3 kg vs -5.7 kg

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Also, 48% of people on Contrave lost at least 5% of their body weight, while only 16% of those on the placebo did