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The glucose-dependence that makes them safe, the central action that drives weight loss, the cardiovascular and renal benefits, and the gastrointestinal side effects all trace back to where the receptor sits and how it signals

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Preclinical models help researchers ask mechanistic questions, but they do not automatically predict human outcomes

Mice (2035 g) were maintained in plastic ventilated cages in a pathogen-free environment (12 h/12 h light/dark cycle, 2124C) at Institut Pasteur de Lille, and had ad libitum access to water and food

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