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The treatment's safety profile is manageable, with gastrointestinal issues being the most frequent side effects, and no new safety concerns have been identified

Cardiovascular outcomes : Semaglutide has demonstrated significant cardiovascular benefits in large randomized controlled trials

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Diet-induced obese (DIO) mice and rats fed a high-fat diet received semaglutide, administered subchronically, and the effects on food intake and BW were evaluated