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Description

This paradoxical improvement occurs because pain reduction outweighs any stimulatory effect on neurotransmitters

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Angelini explains

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N Engl J Med 2025;392:777-87.ArticlePubMed 118

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As per the UK SmPC, the dose is escalated every 4 weeks to reach the target dose of 2.4 mg, with the option to delay a step by 4 weeks if not tolerated

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And we talked about that

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High-dose oral glutathione might only modestly increase blood levels, and standard oral doses often dont significantly raise glutathione in cells

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