Front Pharmacol 15:1347047 Nabrdalik K, Skonieczna-ydecka K, Irlik K, Hendel M, Kwiendacz H, oniewski I, Lip GY (2022) Gastrointestinal adverse events of Metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials
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& Di Virgilio, F
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The trade-off is higher cost and the requirement for clinical administration
This can disrupt normal cellular signaling, impair physiological redox reactions, and even contribute to mitochondrial dysfunction and infertility