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These findings support a mechanistic link between thyroid dysfunction, fibrotic ECM remodeling, and hepatic carcinogenesis, positioning ECM stiffness as a critical pathogenic nexus in the transition from MAFLD to HCC (157)

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For this reason, peptides are often considered more effective for stimulating endogenous collagen synthesis, rather than simply supplying collagen externally

The 4 to 6 hour half-life of BPC-157 means single daily doses create peaks and troughs, while split dosing smooths out this variation