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GATA2 is critical for survival and proliferation of hematopoietic stem cells (77, 78), granulocyte-monocyte progenitor differentiation (79), and basophil and mast cell differentiation (80, 81) and is required for connective tissue mast cell development ( Gata2 -deficient mice ( Gata2 -deficient mice fail to develop both mucosal and connective tissue mast cells, indicating that GATA2 is required for both mucosal and connective tissue mast cell development (Li et al., unpublished data)

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