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Published in The New England Journal of Medicine in May 2025, this landmark study provides definitive evidence about how these two medications compare

However, individual responses vary significantly

This means both sweeteners have the same chemical formula, but the arrangements of their atoms differ slightly

Most researchers prefer the without DAC version for these reasons, despite needing more frequent use

of coffee shop brewed coffee and 50 mg caffeine in 250 ml of brewed black tea (Reference van Dam, Hu and Willett1)

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