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Wu GD, Compher C, Chen EZ, et al

Laser treatment is contraindicated for melasma on Indian skin (Fitzpatrick IIIVI)

aureus secretes a range of exoproteins and proteases, such as V8 protease and hyaluronidase, that degrade ECM components and other host tissues

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Timing of administration relative to surgical procedures, optimal dosing in perioperative settings, and integration with standard post-operative care protocols require clinical investigation before establishing evidence-based perioperative protocols