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Thus, an increase in NRF2 activity, reflected by induction of NRF2 target genes, likely represent an important mechanism mediating the protection seen in GCLM KO mice

13 , e1002087 (2016)

Statistical analysis was performed by G.M.T

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Furthermore, many researchers have found that reduced GSH levels and GSH-dependent antioxidant enzyme activity in damaged myocardium due to excess ROS and disruption of the GSH synthesis process, along with increased oxidative damage and ferroptosis