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Dose-escalation decisions in both phases are evaluated by a Safety Review Committee (SRC) , which assesses clinical, pharmacokinetic and safety data according to predefined stopping rules established in the study protocol

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Therefore, Cys and GSH with high antioxidant activity were selected and subsequent studies were undertaken wherein the hangover-relieving effects of the individual and mixed amino acids were confirmed in in vitro and in vivo models

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Thus, taking steps to reduce kidney stone risk after a first episode is of the utmost importance