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Combination in patients with Type 2 Diabetes Mellitus and Moderate Renal Impairment with Metformin alone, Sulfonylurea alone, Basal Insulin alone or Metformin in Combination with either Sulfonylurea or Basal Insulin In a 26-week, double-blind trial (Trial 5, NCT02827708), 324 adult patients with moderate renal impairment (eGFRCKD-EPI 30 to 59 mL/min/1.73 m2) were randomized to semaglutide tablets 14 mg orally once daily or placebo once daily
Also concerning are semaglutides potential side effects, which can be mild, moderate or severe
Immune Support: Boosts the immune system, improving resistance to infections and diseases
Providers should schedule more frequent follow-up visits during the initial combination period to identify adverse effects early and adjust treatment as needed