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Nutrient Deficiencies : Omeprazole, when taken long-term, can interfere with the bodys ability to absorb certain nutrients, especially vitamin B12 and magnesium

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doi: Spiering, B.A., Kraemer, W.J., Hatfield, D.L., Vingren, J.L., Fragala, M.S., Ho, J.-Y., Thomas, G.A., Hkkinen, K

That may be a rational design for local GI exposure , where systemic bioavailability may not even be the primary objective

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