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PMCID: PMC5609256

Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis

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both an increase in acyl chain order across various membrane models [68,69,70] and a bilayer fluidization after curcumin administration have been reported [71]

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BV hyaluronidase enables the biologically functioning elements in BV to reach the targeted tissues with greater effectiveness by modifying its architectural durability and improving blood supply in the region