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Quick Answer: No single GLP-1 receptor agonist is definitively easiest on the stomach, but dulaglutide and liraglutide may cause slightly fewer gastrointestinal side effects than higher-dose semaglutide or tirzepatide, though individual tolerance varies considerably

However, some women experience an increased heart rate on these medications

The Side Effect in Question: NAION What is NAION

Ipamorelin produced a selective and dose-dependent increase in GH levels with no significant stimulation of ACTH or cortisol, suggesting hypothalamic specificity. Kraemer et al., Journal of Clinical Endocrinology & Metabolism 2

Receptor activation triggers adenylyl cyclase signaling, elevating intracellular cAMP, which activates protein kinase A (PKA) and subsequently the MITF (melanocyte-inducing transcription factor) pathway

Grip strength often decreases, making it difficult to hold objects firmly