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[16] Cerebral folate deficiency [edit] Folinic acid is also used in the treatment of cerebral folate deficiency (CFD), a syndrome of low levels of 5-methyltetrahydrofolate (5-MTHF), the active folate metabolite, within the cerebrospinal fluid (CSF)

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Half-life is relatively dose-independent for both peptides clearance pathways (renal filtration, enzymatic degradation, receptor-mediated endocytosis) operate at fixed rates regardless of dose within the therapeutic range

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