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Venkateswarlu Kanamarlapudi, Swansea University, United Kingdom Updates Copyright 2021 Morrow, Hanson and Mulvihill
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When administered therapeutically, GLP-1 receptor agonists work through several mechanisms: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner [1] [4] Suppressing glucagon release from alpha cells, reducing hepatic glucose output Slowing gastric emptying , which helps moderate post-meal blood glucose rises Promoting satiety through central nervous system pathways, potentially supporting weight reduction Investigational transdermal GLP-1 delivery systems typically utilise specialised technologies such as microneedles or active delivery methods rather than conventional patches, as GLP-1 molecules are large peptides that do not easily penetrate the skin barrier
The following directions of activity are discussed in the preclinical literature: An important caveat: the mechanisms of DSIP are not fully resolved, and the body of evidence is inconsistent