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Absolute contraindications Do not restart semaglutide if you have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Mixing vials : Keep BAC water separate

Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

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Insurance coverage is the biggest wild card

Some patients also use stool softeners or gentle laxatives with medical guidance if needed