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Trial candidates are generally adults with type 2 diabetes and a BMI over 30 who have not achieved adequate glucose or weight control with standard therapies like metformin or a single GLP-1 agonist

10.1016/j.cell.2017.07.050 51 GvozdjakovaA.KucharskaJ.DubravickyJ.MojtoV.SinghR

Nausea peaked at 4348% during weeks 46

When I did that, what I found was not compelling

CrossRef Serum Biomarkers for Hepatocellular Carcinoma: A Comparative Review of Traditional and Emerging Markers Min Kyung Park Journal of Digestive Cancer Research .2025

In trials, they typically achieve significant weight reduction (1520% body weight) and improved glucose control