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In obese PCOS patients, long-term high-fat diets can induce inflammatory reactions and oxidative damage and exacerbate iron deposition, which is an essential factor influencing ferroptosis (158)

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Histopathological analysis at 60 is shown in Figure 3b

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Some practitioners employ intermediate dose increases, such as escalating by 0.25 mg increments rather than doubling doses, to improve tolerance in sensitive patients