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The carnitines are essential in the metabolism of fatty acids and can act to protect from mitochondrial damage and altered energy balance conditions such as those present in polycystic ovary syndrome (PCOS)

However, the original hypothesis linking impaired folate metabolism and abnormal methylation levels of chromosome 21 peri-centromeric regions (James et al., 1999) has not yet been demonstrated, even if in vitro studies revealed that cells under folate deprivation increase the rate of chromosome 21 aneuploidy (Wang et al., 2004

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[6] The second fact reframes the whole comparison