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Effect of LA Supplementation on Ferroptosis in FA-Induced AKI Iron-dependent lipid perioxidation could cause cell necrosis in tubular epithelium (Figure 7, we found that there were more TUNEL-positive tubular cells in the FA group, and the number of TUNEL-positive tubular cells in the low-dose and high-dose LA treatment groups was significantly reduced, while there was no particular preference for the higher-dose group
The main side effects of GLP-1RAs include nausea, diarrhea, and vomiting with injection site pruritus, erythema, and rash being the most common cutaneous side effects
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A cryo-EM structure of Ex4-D-Ala bound to GLP-1R/Gs To investigate the receptor-bound conformation of the potent exendin-4 analogue containing D-Ala in place of Gly4 (referred to below as Ex4-D-Ala), we undertook cryo-EM studies of the complex formed by this agonist with the GLP-1R