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GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and GIP/GLP-1 dual agonists (tirzepatide) anchor the class, with a trial record that includes STEP (semaglutide for weight management, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

By mimicking the GLP-1 hormone, these medications enhance feelings of fullness and reduce hunger

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Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine