glp-1 drug GLP-1s for Weight Loss: What You Need to Know As Interest in GLP-1 Drugs

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Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice

These medications work best in combination with other medications for type 2 diabetes, especially Metformin

Side effects can also occur, such as: Abdominal pain Nausea Vomiting Diarrhea Gastroparesis (delayed stomach emptying) Pancreatitis Possible increased risk of sudden blindness Cost and insurance coverage Health insurance coverage varies widely for GLP-1 medications and can cost a patient hundreds of dollars per month

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However, protection was not to the same extent as observed in direct contact, suggesting involvement of other factors