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Owing to such global re-establishment of methylation patterns, early pregnancy is thought to be particularly sensitive to adverse environmental influences, such as inadequate nutrition or stress, which have been correlated with increased emergence of anxiety, diabetes, obesity, and cancer in adulthood (Jirtle and Skinner, 2007)

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[9] Parenteral administration bypasses the gut entirely

single-source bodies of evidence are more vulnerable to systematic bias and demand independent replication before confident generalization

Additionally, differences between cerebrospinal fluid and fecal lactate levels suggest an incomplete understanding of intestinal lactate metabolisms impact on ME/CFS patients [25, 44, 49]

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