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Draw the desired volume of reconstituted solution, remove any air bubbles by tapping the syringe, and inject at a 45-degree angle into a pinched fold of skin

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Severe AP is characterized by impaired autophagic flux with accumulation of large autophagosomes and overloaded lysosomes, leading to the persistence of dysfunctional mitochondria, excess mtROS, and the release of mitochondrial DAMPs