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Given their established role in regulating hunger and satiety 62,63 and the recent demonstration that the 5-HT2C receptor agonist lorcaserin acts on brainstem GLP-1 neurons to augment food intake suppression by GLP-1R agonism 64 , it seems plausible to hypothesize that weight loss induced by GIPR signal modification may involve modulation of the hypothalamic and/or hindbrain serotonergic system
While short-term human preclinical studies indicate beneficial effects on muscle and tissue repair, ongoing medical monitoring is essential to maintain balanced hormone and glucose levels
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