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Some thoughts... This new study is consistent with studies showing NMN, an NAD booster & SIRT1 activator, improves bone mass in miceThis paper summarizes the evidence that GLP1RA drugs benefits boneNMN has been shown in mice to improve healing of broken bones..And this one on SIRT1's benefits on bone:But be aware that these drugs can have negative side effects on the kidney, muscle and even increase the chances of sudden blindness!Another side effect of GLP-1RA is muscle loss

Diabetologia 2016;59:426435 [DOI] [PMC free article] [PubMed] [Google Scholar] 42.MacConell L, Gurney K, Malloy J, Zhou M, Kolterman O

Factors such as current gut health, diet, stress levels, exercise habits, and sleep quality all influence how quickly and profoundly results may manifest

So Gary, when we talk about mechanisms and we talk and how David relates it to low-carb diets, how do you see that fitting into the picture to say, yes, theyre basically another version of low-carb diets, or is there or more to it

While prevention is paramount, this growing mechanistic framework raises hypotheses for future studies that targeting mitochondrial metabolism can open windows of epigenetic plasticity toward more positive health outcomes, particularly in subjects with a history of adverse childhood experiences

Characteristics, comorbidities, and correlates of atypical depression: evidence from the UK biobank mental health survey