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225,226,227,228 Backbone modification The modification strategies used in first-generation NADs have focused on modification of the phosphate backbone, mainly using other types of groups to replace the non-bridging oxygen atoms in the phosphate backbone, such as phosphorothioate (PS), methyl phosphate, and boranophosphate

Therapeutic strategies targeting the MGB axis, including prebiotics, synbiotics, and fecal microbiota transplantation, are not universally applicable

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Look for co-factors like Selenium and Vitamin C

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Interleukin-2