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10.3390/nu12030605 32 SaviniM.CecchiniC.VerdenelliM

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Its high receptor selectivity for MC1R relative to MC3R, MC4R, and MC5R distinguishes it mechanistically from Melanotan II in research settings

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IL-6, secreted from cardiac fibroblasts, contributes to cardiac hypertrophy through the p38 MAPK pathway, which regulates pro-inflammatory cytokine biosynthesis at the transcriptional and translational levels [8, 18]