The pathological state of glial cells regulates the bloodbrain barrier (De Bock et al., 2017) and therefore these cells can be thought of as guardians that protect neurons against oxidative stress (Liu et al., 2018) via the Saposin C/GPR37L1/GPR37 pathway
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At the lowest tested concentration of 0.1% APTES, during the first 3 hours the max peak wavelength of the control and experimental trials were maintained at approximately 500 nm
Mller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, et al
10.3892/etm.2018.6512 Exp Ther Med
Probiotics counteract this effect by generating SCFAs such as butyrate and propionate, which are HDAC inhibitors