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In DXA body-composition analyses from the STEP 1 semaglutide program and the SURMOUNT-1 tirzepatide trial, lean mass decreased alongside fat mass, and the STEP 1 extension showed that many participants regained about two-thirds of their lost weight after stopping semaglutide, which is one more reason to protect muscle and training habits while the medication is working

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Intracellular ROS is also linked to immunogenic cell death and M2 to M1 polarization in macrophages is believed to be critical for immunomodulation in tumor inhibition